Identification of Gene, Function & Pathogen

Question starts from:

gctcgtgcga gcgggcctac cgacggccgc gcggcgtccc 421 gtcctagcca tcgccagggg gcctccgaag cccgcgggga tccggagctg cccacgctgc 481 tgcgggttta tatagacgga ccccacgggg tggggaagac caccacctcc gcgcagctga 541 tggaggccct ggggccgcgc gacaatatcg tctacgtccc cgagccgatg acttactggc 601 aggtgctggg ggcctccgag accctgacga acatctacaa cacgcagcac cgtctggacc 661 gcggcgagat atcggccggg gaggcggcgg tggtaatgac cagcgcccag ataacaatga 721 gcacgcctta tgcggcgacg gacgccgttt tggctcctca tatcgggggg gaggctgtgg 781 gcccgcaagc cccgcccccg gccctcaccc ttgttttcga ccggcaccct atcgcctccc 841 tgctgtgcta cccggccgcg cggtacctca tgggaagcat gaccccccag gccgtgttgg 901 cgttcgtggc cctcatgccc ccgaccgcgc ccggcacgaa cctggtcctg ggtgtccttc 961 cggaggccga acacgccgac cgcctggcca gacgccaacg cccgggcgag cggcttgacc 1021 tggccatgct gtccgccatt cgccgtgtct acgatctact cgccaacacg gtgcggtacc 1081 tgcagcgcgg cgggaggtgg cgggaggact

• Gene Name: TK


• Protein Name: Thymidine kinase (Also known as: EC 2.7.1.21)
  


• Gene Function:
  1. Thymidine kinase activity. Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
  2. ATP binding. Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


• Protein Function:
  In latent infection, thymidine kinase protein may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome .

Figure: Human Herpesvirus.
CST: Urinary Tract Infections and Sexually Transmitted Infections.

• Pathogen: Human herpesvirus 2 strain 333
  Taxonomy ID: 10313
  Rank: no ranks
  Genetic code: Translation table 1 (Standard)
  Other names:
  synonym: Herpes simplex virus (type 2 / strain 333)
  synonym: human herpesvirus 2 (strain 333)
  Lineage( full )
  Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Alphaherpesvirinae; Simplexvirus; Human herpesvirus 2

References:
1. UniProtKB, April 8, 2008: Reviewed, UniProtKB/Swiss-Prot P04407(KITH_HHV23). Internet: http://beta.uniprot.org/uniprot/P04407.
2. EMBL-EBI, 1995: IPR001889 Herpesvirus thymidine kinase. Internet: http://www.ebi.ac.uk/interpro/ISearch?mode=ipr&query=IPR001889.
3. NCBI: Human Herpesvirus 2 strain 333. Internet: http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10313&lvl=3&lin=f&keep=1&srchmode=1&unlock.
4. NCBI: X01712. Internet: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=59898.

Comments and inquiries are always welcome.

Prepared by Tan Phit Ling 1071114866